ABSTRACT
BACKGROUND/OBJECTIVE: Skeletal metastasis is one of the major clinical problems in managing cases of NPCA. Beginning osseous metastasis in the form of sphenoid bone extension is commonly seen in NPCA.Imaging modalities mainly used in detecting sphenoid bone extension are bone scintigraphy with SPECT and MRI. In this paper, the ability of bone scintigraphy with SPECT and MRI in detecting sphenoid bone extension was compared.MATERIALS AND METHODS: Twelve patients with nasopharyngeal carcinoma were studied by bone scintigraphy with SPECT and MRI. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of each modality against the gold standard, which is sphenoid bone biopsy, were computed. Statistical analysis was done using the McNemar's Test.RESULTS: The overall performances of bone scintigraphy with SPECT versus MRI were the following: sensitivity 89% vs 78%, specificity 33% vs 67%, positive predictive value 80% vs 88% and negative predictive value 50% vs 50%. There was no significant difference between the two modalities using McNemar's test (p>0.05).CONCLUSION: Bone scintigraphy with SPECT and MRI were both equally effective and were complementary with each other in detecting sphenoid bone extension in patients with NPCA.
Subject(s)
Humans , Male , Female , Middle Aged , Adult , Nasopharyngeal Carcinoma , Tomography, Emission-Computed, Single-Photon , Sensitivity and Specificity , Nasopharyngeal Neoplasms , Bone Neoplasms , Sphenoid BoneABSTRACT
Lung hernia is a rare finding described as the protrusion of lung tissue outside the pleural cavity. Lung perfusion scintigraphy is used for pre-operative assessment of high-risk patients prior to pneumonectomy This case report presents a case of an apical left lung hernia detected in a lung perfusion scan prior to elective pneumonectomy in a seven-year-old girl with pulmonary tuberculosis destroyed right lung and compensatory left lung hyperinflation.